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Xpert® FII & FV

FII & FV computer generated depiction.
30-Minute Test for Genetic Risk of Thrombosis

The Need

an ill woman listens to a physician
Thrombophilia is as an increased risk or tendency to develop blood clots (thrombi) in veins, arteries or both due to either inherited or acquired defects.1

The high incidence of venous thrombo-embolism (VTE) in hospitalized patients is a major cause of sudden death.1

Factor II and V are the two most common genetic variants associated with VTE and testing for these variants is one of the most commonly performed genetic tests in laboratories evaluating thrombophilia.3
  1. Heit J et al. The epidemiology of venous thromboembolism. J Throm Thrombolysis 2016 41: 3-14
  2. CDC. Accessed Aug 2020 https://www.cdc.gov/ncbddd/dvt/facts.html
  3. Zhang S, Taylor AK, Huang X, Luo B, Spector EB, Fang P, Richards CS; ACMG Laboratory Quality Assurance Committee. Venous thromboembolism laboratory testing (factor V Leiden and factor II c.*97G>A), 2018 update: a technical standard of the American College of Medical Genetics and Genomics (ACMG). Genet Med. 2018 Dec;20(12):1489-1498. doi: 10.1038/s41436-018-0322-z. Epub 2018 Oct 5. PMID: 30297698.
  4. Saquilayan M et al. Detection of genetic thrombophilia (Fa V Leiden & PT20210 mutation) using GeneXpert technology with IQCP implementation. Natural Sciences and Mathematics | Clinical Laboratory Sciences Culminating Projects. 2019. https://doi.org/10.33015/dominican.edu/2019.CLS.04

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